SD大鼠
起源1925年Robert W.Dawley将一只杂种雄性和一只雌性Wistar大鼠交配，得到该品系。
特征与用途
◇解剖：头部狭长，尾长接近于体长，产仔多，生长发育较Wistar快。
◇免疫：抗病能力强，尤其对呼吸道疾病的抵抗力强。
◇肿瘤：自发肿瘤发生率低。
◇生理：对性激素敏感性高。
◇用途：常用作营养学，内分泌学和毒理学等方面的研究。
饲料大小鼠繁殖料
来源于查氏瑞华大鼠的生长曲线：
来源于Taconic大鼠的生长曲线和生理指标：
Average litter size:10
SD Physiological Data Summary (April 2004; N=10/group):
ParameterUnitsSprague
Dawley® MalesSprague
Dawley® Females
Serum Chemistry
Avg ± S.D.
Calcium
mg/dL
12.3 ± 0.4
11.4 ± 3.5
Phosphorous
mg/dL
12.6 ± 1.1
12.4 ± 1.4
Glucose
mg/dL
82.4 ± 11.3
93.2 ± 10.3
Creatinine
mg/dL
0.3 ± 0.1
0.3 ± 0.1
BUN
mg/dL
9.1 ± 1.4
13.6 ± 3.0
Total Bilirubin
mg/dL
0.1 ± 0.0
0.1 ± 0.0
ALK
U/L
227.7 ± 36.1
142.5 ± 33.9
ALT U/L
U/L
29.3 ± 3.4
22.5 ± 3.9
Total Protein
g/dL
6.4 ± 0.2
6.7 ± 0.2
Blood Counts
Erythron
Red Blood Cells
X106/uL
6.9 ± 0.3
7.7 ± 0.3
Nucleated RBC
X106/uL
0
0
Hemoglobin
g/dL
14.5 ± 0.8
16.1 ± 0.6
Hematocrit
%
48.3 ± 2.3
51.2 ± 2.6
MCV
fL
69.9 ± 1.7
66.9 ± 0.9
MCH
pG
20.9 ± 1.3
21.0 ± 1.1
MCHC
%
29.9 ± 1.6
31.4 ± 1.9
Platelets
Platelets
X103/uL
1358.0 ± 123.8
1262.2 ± 278.4
Leukogram
White Blood Cells
x103/uL
9.4 ± 3.2
6.0 ± 1.5
Neutrophil
x103/uL
0.9 ± 0.5
0.4 ± 0.3
Bands
x103/uL
0
0
Lymphocyte
x103/uL
8.3 ± 2.9
5.5 ± 1.4
Monocytes
x103/uL
0.3 ± 0.3
0.1 ± 0.1
Eosinophil
x103/uL
0
0
Basophils
x103/uL
0
0
Others
x103/uL
0
0
Organ Weights
Stomach
g
2.02 ± 0.12
1.54 ± 0.17
Ileum
g
6.19 ± 0.62
4.83 ± 0.35
Colon
g
0.77 ± 0.37
0.85 ± 0.21
Lungs
g
1.69 ± 0.14
1.31 ± 0.19
Heart
g
1.24 ± 0.14
0.90 ± 0.10
Liver
g
11.37 ± 1.12
7.17 ± 0.62
Spleen/Pancreas
g
1.58 ± 0.15
1.17 ± 0.23
Kidney (L)
g
1.08 ± 0.1
0.82 ± 0.08
Kidney (R)
g
1.09 ± 0.09
0.85 ± 0.08
Testes (L)
g
1.33 ± 0.17
-
Testes (R)
g
1.33 ± 0.14
-
Ovary (L)
g
-
0.08 ± 0.01
Ovary (R)
g
-
0.08 ± 0.01
Urinalysis
Glucose
mg/dL
Negative
Negative
Blood
-
Negative
Negative
pH
-
6.75 ± 0.35
6.7 ± 0.4
Protein
mg/dL
N/A
N/A
Specific Gravity
-
1.0195 ± 0.0068
1.0155 ± 0.0079
One Year Growth Chart
Taconic Sprague Dawley® Rats Average Control Group Body Weight in Grams
One Year Toxicology Study (N=20)
Weeks of Age678910
Female
152.71
184.13
209.71
227.55
241.11
Male
163.01
225.98
276.15
306.93
336.53
Weeks of Age1112131415
Female
256.33
260.37
271.94
279.08
291.5
Male
361.71
378.11
396.8
412.86
431.21
Weeks of Age1617182226
Female
295.22
298.41
303.42
315.48
335.41
Male
441.56
454.14
461.01
491.98
514.05
Weeks of Age3034384246
Female
350.74
357.83
368.19
383.44
392.05
Male
528.94
544.33
556.88
568.96
568.41
Weeks of Age505458
Female
408.44
421.01
426.79
Male
579.1
584.42
577.79
来源于Charles River大鼠的生长曲线和生理指标：
CDIGSRatModelInformationSheet.pdf
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