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宠物猫/狗单克隆抗体开发

萌宠菠菠乐园
2024-12-14 01:28

服务类型具体项目服务周期交付内容直接淘选兔天然scFV噬菌体抗体文库淘选2-4周

阳性菌株1-3株

序列1-3条

服务报告

羊驼纳米抗体天然VHH文库淘选7肽库和12肽噬菌体文库淘选犬scFV噬菌体抗体文库淘选猫scFV噬菌体抗体文库淘选建库+淘选

噬菌体文库构建及淘选：人，兔，小鼠，羊驼，犬，猫，鸡，猪等

12-14周

免疫文库

阳性菌株5-10株

序列5-10条

服务报告

部分订购普健生物单抗开发服务已发表文献

噬菌体展示路线

1. Li, L., Gao, M., Li, J., Zu, S., Wang, Y., Chen, C., Wan, D., Duan, J., Aliyari, R., and Wang, J. (2021). Methods to Identify Immunogenic Peptides in SARS‐CoV‐2 Spike and Protective Monoclonal Antibodies in COVID‐19 Patients. Small Methods 5, 2100058.

2. Luo, K., Chen, Y., and Wang, F. (2022). Shrimp plasma MANF works as an invertebrate anti-inflammatory factor via a conserved receptor tyrosine phosphatase. The Journal of Immunology 208, 1214-1223.

杂交瘤路线

3. Du, Y., Peng, Q., Cheng, D., Pan, T., Sun, W., Wang, H., Ma, X., He, R., Zhang, H., Cui, Z., et al. Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells. Nature communications 13, 231.

4. Gao, Y., Wang, Y., Lei, H., Xu, Z., Li, S., Yu, H., Xie, J., Zhang, Z., Liu, G., and Zhang, Y. (2023). A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau. Translational Neurodegeneration 12, 51.

5. Gou, Y., Li, F., Huo, X., Hao, C., Yang, X., Pei, Y., Li, N., Liu, H., and Zhu, B. (2021). ENO1 monoclonal antibody inhibits invasion, proliferation and clone formation of cervical cancer cells. American Journal of Cancer Research 11, 1946.

6. Peng, Q., Pan, T., He, R., Yi, M., Feng, L., Cui, Z., Gao, R., Wang, H., Feng, X., and Li, H. (2023). BTNL2 promotes colitis‐associated tumorigenesis in mice by regulating IL‐22 production. EMBO reports 24, e56034.

7. Shu, F., Li, Y., Chu, W., Chen, X., Zhang, Z., Guo, Y., Feng, Y., Xiao, L., and Li, N. (2022). Characterization of calcium-dependent protein kinase 2A, a potential drug target against cryptosporidiosis. Frontiers in Microbiology 13, 883674.

8. Wang, Y., Liu, C., Zhang, N., Song, X., Song, Y., Cai, D., Fang, K., and Chang, X. (2022). Anti-PADI4 antibody suppresses breast cancer by repressing the citrullinated fibronectin in the tumor microenvironment. Biomedicine & Pharmacotherapy 153, 113289.

9. Wang, Y., Song, X., Song, Y., Fang, K., and Chang, X. (2023). Investigating the cell membrane localization of PADI4 in breast cancer cells and inhibition of anti-PADI4 monoclonal antibody. Journal of Cancer Research and Clinical Oncology 149, 17253-17268.

10. Zhang, X.-Y., Cui, Z.-W., Zhou, Y.-Y., Chen, D.-D., and Zhang, Y.-A. (2021). Neutrophil functions can be regulated by IL-35, which is mainly expressed in IL-15Rα+ cells in grass carp (Ctenopharyngodon idella). Developmental & Comparative Immunology 121, 104103.

兔单B路线

11. Guo, N., Tang, S., Wang, Y., Chen, W., An, R., Ren, Z., Hu, S., Tang, S., Wei, X., Shao, G., et al. (2024). A mediator of OsbZIP46 deactivation and degradation negatively regulates seed dormancy in rice. Nature Communications 15, 1134.